The college provides special facilities to support the independent work and mobility of differently abled students. Students with disabilities or who are differently abled have equal access to all college schemes, facilities, and services. To cater to their unique needs, the college has created accessible infrastructure, including ramps, handrails, and adapted washrooms, and made necessary modifications as required.

The library and reading room at De Paul College reserve special seating facilities for differently abled students, ensuring easy accessibility. These students are also granted permission to access books and resources as per their requirements, facilitating a supportive and inclusive learning environment.